The BICCN actively supports data processing, mapping, and analysis standards including FAIR (findable, accessible, informative and reusable) data. The Brain Cell Data Center (BCDC) has established active standards working groups within the BICCN. Well defined and standardized metadata is the basis for promoting scientific reproducibility and identifying data provenance and is a critical aspect of any larger scientific data organization. Metadata in BICCN comprises a range of data description from experimental protocol, choice of instrumentation, genetic tools, and data attribute descriptors. To make concrete progress and retain high utility the BICCN will structure metadata organization incrementally, addressing minimal and essential aspects first and building on developing standards as needs arise. There are three primary areas of interest.
A. Establish semantic and spatial community standards for description and management of single cell data modalities.
- Working with BICCN data providers, create and promote consistent data description standards that describe and facilitate best practices for community use of multi-modal single cell data and its content.
- Partnering with the Neuroscience Information Framework (NIF), International Neuroinformatics Coordinating Facility (INCF), Neurodata without Borders (NWB) and other standards promoting organizations, rapidly deploy protocols and formats building upon existing standards to allow external data contributors and the community to utilize the BCDC.
- Encourage and adopt FAIR data practices and standards in the establishment of an Integrated Data Set (IDS).
B. Develop and extend common coordinate frameworks (CCF) based on searchable digital atlases for data mapping, access, and navigation.
- Refine and extend the 3-D Allen Institute Common Coordinate Framework for the mouse to enable external mapping of key single cell modalities in a 2D and 3D anatomic context for access and visualization at cell, and nuclei level.
- Assist with cell- and image- based mapping and navigation tools for cell location, context and ontology relationships.
- Develop and deploy mapping frameworks for the human and nonhuman primate as atlas sets and standards become available.
C. A key endpoint for the BICCN is the generation of an Integrated Data Set (IDS) that enables the study of correspondence between the BICCN data modalities.
- The IDS will form the basis for detailed investigation of comparative cellular resolution attributes combining them so as to maximize ability to deduce cell type identity.
- The IDS will be the main entry point for high resolution data of the BCDC synergizing the data beyond a more limited to a collection of site specific data sets.