Science Together

Explore the growing set of cutting-edge scientific packages developed as major outcomes of the BICCN's collaborative efforts.  Discover how these powerful datasets are revolutionizing our understanding of the brain and its cell types.

Whole Mouse Brain Atlas

Nature - Dec 14, 2023

The current collection of papers from BICCN researchers reports the first complete cell type atlas of a mammalian brain, with over 30 million cells profiled from the adult mouse brain using a combination of single-cell transcriptomic, epigenomic, and spatial transcriptomic approaches, identifying over 5,300 cell types in the entire mouse brain. These studies achieve brain-wide cross-modality integration between transcriptomic profiles and epigenomic, spatial, or connectional properties, as well as certain aspects of evolutionary conservation and divergence, and uncover multitudes of organizing principles of the extraordinary cell type diversity across the brain.

Human and Non-Human Primate Cell Atlas

Science, Science Advances, and Science Translational Medicine - October 13, 2023

With over 100 billion neurons in the human brain, understanding the cellular diversity and differences between human and non-human primate (NHP) brain will lay a key foundation for future brain and disease research. This curated collection of studies is dedicated to deciphering the nuanced gene expression by species and age and functional and anatomical properties that delineate these cell types.

Cell Census of the Primary Motor Cortex

Nature - October 6, 2021

A multimodal cell census and atlas of the mammalian primary motor cortex (MOp or M1) was achieved as the initial product of the BRAIN Initiative Cell Census Network (BICCN). Coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties, and cellular resolution input-output mapping, integrated through cross-modal computational analysis.